12 MINIREVIEW Current Prospects for the Fluoroquinolones as First-Line Tuberculosis Therapy Howard Takiff* and Elba Guerrero Instituto Venezolano de Investigaciones CientÃ?cas (IVIC), Caracas, Venezuela and by adding variant side groups literally thousands of intelligible ?uoroquinolones were synthesized. Although the increased broad-spectrum activity of cipro?oxacin (CIP) created the prevision that it would be a high-priced agent against troublesome bacteria such as Staphylococcus aureus, resistance in these bacteria highly-developed rapidly. Within just a few years after(prenominal) the introduction of CIP, many nosocomial strains (9) were resistant (10), especially Gram-positive bacteria. In contrast, CIP has remained effective much time-consuming against some enteric Gramnegative bacteria, such as Escherichia coli (49). The difference appeared to be concern to the ratio of the usual blood serum drug concentration to the innate MIC of the bacteria. The...If you assertion to get a full(a) essay, order it on our website: Orderessay
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